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Travelers overlooking Machu Picchu

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Cusco and Puerto Maldonado

Two cities, two regions of Peru and a single overnight journey between them.

Highlands · 3,399 m a.s.l.
Inca walls of Sacsayhuamán in Cusco
Machu Picchu citadel

Destination

Cusco

The former capital of the Inca Empire and one of the most visited cities in Peru. It is the starting point for Machu Picchu, the Sacred Valley and the archaeological sites around the city.

What to see

  • Machu Picchu
  • Sacred Valley of the Incas
  • Sacsayhuamán
  • Plaza de Armas and historic center
  • San Blas neighborhood
  • Rainbow Mountain
Arrive atCusco Bus Terminal
Departs Pto. Maldonado18:30
Altitude3,399 m a.s.l.
Jungle · 183 m a.s.l.
Amazon river in Madre de Dios
Suspension bridge over the Amazon rainforest

Destination

Puerto Maldonado

The capital of Madre de Dios, on the banks of the Madre de Dios and Tambopata rivers. It is the gateway to Peru’s southern Amazon, with nature reserves, lakes and lodges deep in the rainforest.

What to see

  • Tambopata National Reserve
  • Lake Sandoval
  • Madre de Dios River
  • Macaw clay licks
  • Canopy suspension bridges
  • Amazonian cuisine
Arrive atPuerto Maldonado Bus Terminal
Departs Cusco20:30
ClimateHot and humid

Before you travel

Tips for the journey

The trip crosses from the highlands to the jungle in a single night, so it is worth preparing for two different climates.

Bring a layer for the bus

The bus is climate-controlled overnight. Keeping a jacket or blanket at hand makes resting more comfortable.

Acclimatize in Cusco

If you are arriving in Cusco, take your first day easy to adjust to the altitude before going on excursions.

Get ready for the jungle

If you are heading to Puerto Maldonado, bring light clothing, insect repellent and sunscreen for the heat and humidity.

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